Drugs found to both prevent and treat Alzheimer's disease in mice

Drugs found to both prevent and treat Alzheimer's disease in mice

The drugs, known as "TSPO ligands," are currently used for certain types of neuroimaging.

"We looked at the effects of TSPO ligand in young adult mice when pathology was at an early stage, and in aged mice when pathology was quite severe," said lead researcher Christian Pike of the USC Davis School of Gerontology. "TSPO ligand reduced measures of pathology and improved behavior at both ages."

The team's findings were published online by the Journal of Neuroscience on May 15. Pike's coauthors include USC postdoctoral scientists Anna M. Barron, Anusha Jayaraman and Joo-Won Lee; as well as Donatella Caruso and Roberto C. Melcangi of the University of Milan and Luis M. Garcia-Segura of the Instituto Cajal in Spain.

The most surprising finding for Pike and his team was the effect of TSPO ligand in the aged mice. Four treatments -- once per week over four weeks -- in older mice resulted in a significant decrease of Alzheimer's-related symptoms and improvements in memory -- meaning that TSPO ligands may actually reverse some elements of Alzheimer's disease.

"Our data suggests the possibility of drugs that can prevent and treat Alzheimer's," Pike said. "It's just mouse data, but extremely encouraging mouse data. There is a strong possibility that TSPO ligands similar to the ones used in our study could be evaluated for therapeutic efficacy in Alzheimer's patients within the next few years."

Next, the team will next focus on understanding how TSPO ligands reduce Alzheimer's disease pathology. Building on the established knowledge that TSPO ligands can reduce inflammation -- shielding nerve cells from injury and increasing the production of neuroactive hormones in the brain -- the team will study which of these actions is the most significant in fighting Alzheimer's disease so they can develop newer TSPO ligands accordingly.

Welcome to SUV System Ltd!

SUV System Ltd is ISO 90012008 Certified electronics distributor with 10 years of experiences.

We have built up long term business relationship with about many companies which are stockers and authorized agents. we have a steady and reliable supply to meet customer's demands to the greatest extent .Confidently, we are able to lower your cost and support your business with our years of professional service.

SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com

Electronic Components distributor:http://www.suvsystem.com

Connectors Distributor:http://www.suvsystem.com/l/Connectors-1.html

IC Distributor:http://www.suvsystem.com/l/IC(Integrated-Circuits)-1.html

LED Distributor:http://www.suvsystem.com/l/LED-1.html

Capacitor Distributor:http://www.suvsystem.com/l/Capacitor-1.html

Transistor Distributor:http://www.suvsystem.com/l/Transistors-1.html

Resistor Distributor:http://www.suvsystem.com/l/Resistors-1.html

Diode Distributor:http://www.suvsystem.com/l/Diodes-1.html

SUV System Ltd insists on the managing faith ofsincereness,speciality,foresight, win-win,so we build up stable-relationship customers located all over the world, including the States, Europe, Argentina, UAE, Malaysia, Australia,and India etc

we are focus on the following fields,and hope we can help you.

CS42418-CQZ CS42416-DQZR CS42416-DQZ CS42416-CQZR CS42416-CQZ CS42325-CQZREnd of Life CS42325-CQZR CS42325-CQZEndofLife CS42325-CQZ CS42324-CQZREnd of Life CS42324-CQZR CS42324-CQZEndofLife CS42324-CQZ CS42L51-CNZ CS4299-JQZR CS4299-JQZ CS4299-BQZR CS4299-BQZ CS42888-DQZR CS42888-DQZ CS42888-CQZR CS42888-CQZ CS4272-DZZR CS4272-DZZ CS4272-CZZR CS4272-CZZ CS4271-DZZR CS4271-DZZ CS4271-CZZR CS4271-CZZ CS4270-DZZR CS4270-DZZ CS4270-CZZR CS4270-CZZ CS4265-DNZR CS4265-DNZ CS4265-CNZR CS4265-CNZ CS42528-DQZRNRND CS42528-DQZNRND
http://www.suvsystem.com/a/1256.aspx